Individual Filter Vial Press
From LEAP
| Sample Filtration |
| Application Type | |
| SPECIAL | |
| Application ID | |
| LEAP X-Press | |
| Description | |
| Sample Filtration with LEAP X-Press Individual Filter System |
Contents |
Overview
Whatman Mini Uniprep syringeless filters offer a convenient way of filtering samples containing particulates prior to introduction on an HPLC system. It combines filtration and storage into one simple device that can be integrated with the PAL. They come with 2 pore sizes and many different filter media. They are designed for manual operation but are not conducive to large batch sizes - repeated pressing by hand being very fatiguing.
Mini Uniprep consists of a 0.4 ml capacity chamber and a plunger. The plunger contains a filtration membrane at one end and a pre-attached cap/septum at the other. The plunger is pressed through the sample in the outer chamber and positive pressure forces the filtrate into the reservoir of the plunger. Air escapes through the vent hole until the locking ring is engaged providing an air-tight seal. (see Diagram)
LEAP has developed a "Press" accessory,LEAP X-Press, for the PAL which allows samples to be filtered reliably and repeatably. It does not require external pneumatics, but uses the PAL Z motion itself to compress the filter chambers. Samples can be processes in batch mode or "just in time" before direct injection to the LC valve.
The PAL offers precise control of the down force on the sample. The user can specify the speed of compression in the method, allowing even very heavy suspensions to be filtered successfully.
The complete system can provide automated online filtration, including sample preparation, sample transport and injection into the chromatographic system.
Info on LEAP X-Press
Features and Benefits
- Ease of use Filtering and storage vial allows you to process sample loads in one-third the time
- Wide range of membranes Suits a variety of sample types
- Available in 0.2 and 0.45 μm pore sizes Meets specific sample requirements
- Compatible with all major autosamplers Allows you to speed processes
- Fewer consumables required Lowers Costs by up to 40 percent
- Slit septa cap - Enables Mini-UniPrep use with current robotics on HPLC instruments for high throughput automation
- Slit septa cap - Increases needle longevity Eliminates coring problems associated with repeated sampling
- Slit septa cap - Durable yet flexible and has been specially designed for instruments with sensitive sampling needs
The self-sealing septa of the UniPrep allows for repeated injections: Prevents evaporation and maintains sample integrity. Whatman Mini-UniPrep Syringeless Filters offer a highly efficient, simple alternative for removing unwanted protein prior to HPLC/MS analysis. Ideal for performing analytical characterization in drug research, the method utilizes acetonitrile precipitation and filtration by compression to remove protein from plasma, serum, whole blood, and other biological fluids. It is a single tube method that saves time and eliminates the manual transfer steps which make spin clarification problematic.
Significant Markets
Any labs who are doing High Performance Liquid Chromatography (HPLC) or more significantly, Ultra High Performance Liquid Chromatography (UHPLC) analysis. It is imperative that particles are eliminated to avoid blockage of HPLC lines and columns. This filtering technique let you prepare samples in one third the time required by other methods. Automation of the filtering step has NOT been possible in a reliable fashion till now.
Possible Markets
- Cosmetics
- Food & Beverage
- Pharmaceutical
- Routine analysis
- Composite assays
- Content uniformity
- Protein precipitation
- Solubility testing
- Dissolution testing
- Sample filtration
Photos
LEAP X-Press option on PAL |
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More Info
Whatman Uniprep Website
Whatman UniprepSellSheet
Videos
Movie of the Press in action on YouTube
LEAP's PAL Application Videos on YouTube
Accessories for the PAL
Other Accessories for PAL Robots
LEAP provides automated workstation instrumentation solutions based on the LEAP CTC PAL X, Y, Z syringe only autosampler robot from LEAP Technologies. This extremely flexible, precise, and adaptable liquid handling robotic platform is available in a variety of lengths and options depending on the requirements of your sample preparation and injections for your UHPLC, LC or GC chromatography. LEAP offers full support and service for the PAL platform in addition to being able to write custom macros, cycles, and scheduling to your applications.Please contact LEAP Technologies on how we can help you get maximized throughput with flexible pipetting automation solutions.
Contact LEAP
 Contact LEAP
For additional information about LEAP and the PAL Platform, please contact LEAP Technologies. |
