Summary of LC Multi Valve Applications

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LC Multiple Valve Applications
Application Type
  STANDARD AND SPECIAL
Application ID
 
Description
  Multiple Valve Applications for LC


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-001[1] Dual Channel Serial Injection

Provides shorter cycle times by regenerating columns during next analytical run
Analyst with ICC-CE * 6 port injection valve
* 10 port Valve
* Gradient Pump
* Regeneration pump
* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected
* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples
Yes
Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-002 Dual Channel Serial Injection with Front Cut

Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste
Analyst with ICC-CE * Trio VS
* Gradient Pump
* Regeneration pump
* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected
* Avoids contaminating MS inlet with early eluting compounds and solvent
* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples
Yes


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-003 Dual Channel Parallel Injection

Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
Cycle Composer outside of Analyst * DoubleStack valve
*6 port injection valve
*FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump
* Saving of Front and Back Cut
* Provides "Look Ahead"
*Provides staggering of injections
* Requires matching sample lists in Cycle Composer and Analyst
* Columns may perform slightly differently on alternating samples
No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-005 Dual Channel Parallel Injection

Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
LEAP Shell *DoubleStack valve
*6 port injection valve
*FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump
*Integration with Analyst Software
*Single Sample List
*Provides staggering of injections
*Multiplexes 2 separate LC systems into on MS
* Does not support 21CFR11 compliance
*Requires pumps to be integrated with LEAP Shell
No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-005 Dual Channel Parallel Injection

Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
LEAP Shell *DoubleStack valve
*6 port injection valve
*FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump
*Integration with Analyst Software
*Single Sample List
*Provides staggering of injections
*Multiplexes 2 separate LC systems into on MS
* Does not support 21CFR11 compliance
*Requires pumps to be integrated with LEAP Shell
No



For other cost/time saving measures consider:

  • LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [2]
  • Dual Channel Serial Injection (M-001) using Analyst and ICC-CE [3]
  • Dual Channel Serial Injection with Front Cut (M-002) using Analyst and ICC-CE [4]
  • Dual Channel Parallel Injection (M-003) using Cycle Composer Software and Analyst [5]
  • “Look Ahead”, sample prep before injection (M-004) using LEAP Shell Software [6]
  • Dual Channel Parallel Injection (M-005) using LEAP Shell software [7]
  • LEAP Shell Software and application for custom injections and scheduling [8]

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Contact LEAP

For additional information about this technique please contact LEAP Technologies for detailed information

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