Summary of LC Multi Valve Applications
From LEAP
| LC Multiple Valve Applications |
| Application Type | |
| STANDARD AND SPECIAL | |
| Application ID | |
| Description | |
| Multiple Valve Applications for LC |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-001 | Dual Channel Serial Injection Provides shorter cycle times by regenerating columns during next analytical run | Analyst with ICC-CE | * 6 port injection valve * 10 port Valve * Gradient Pump * Regeneration pump | * Saving of regeneration time(Back Cut) * Increase throughput at little cost * Control is all within Analyst * Compliance is not affected | * Can not do "Look Ahead" * Injections are not staggered * Peaks of interest must come of early * Columns may perform slightly differently on alternating samples | Yes |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-002 | Dual Channel Serial Injection with Front Cut Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste | Analyst with ICC-CE | * Trio VS * Gradient Pump * Regeneration pump | * Saving of regeneration time(Back Cut) * Increase throughput at little cost * Control is all within Analyst * Compliance is not affected * Avoids contaminating MS inlet with early eluting compounds and solvent | * Can not do "Look Ahead" * Injections are not staggered * Peaks of interest must come of early * Columns may perform slightly differently on alternating samples | Yes |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-003 | Dual Channel Parallel Injection Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition | Cycle Composer outside of Analyst | * DoubleStack valve *6 port injection valve *FWS in front of 6 port valve * Gradient Pump * Regeneration pump | * Saving of Front and Back Cut * Provides "Look Ahead" *Provides staggering of injections | * Requires matching sample lists in Cycle Composer and Analyst * Columns may perform slightly differently on alternating samples | No |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-005 | Dual Channel Parallel Injection Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition | LEAP Shell | *DoubleStack valve *6 port injection valve *FWS in front of 6 port valve * Gradient Pump * Regeneration pump | *Integration with Analyst Software *Single Sample List *Provides staggering of injections *Multiplexes 2 separate LC systems into on MS | * Does not support 21CFR11 compliance *Requires pumps to be integrated with LEAP Shell | No |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-005 | Dual Channel Parallel Injection Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition | LEAP Shell | *DoubleStack valve *6 port injection valve *FWS in front of 6 port valve * Gradient Pump * Regeneration pump | *Integration with Analyst Software *Single Sample List *Provides staggering of injections *Multiplexes 2 separate LC systems into on MS | * Does not support 21CFR11 compliance *Requires pumps to be integrated with LEAP Shell | No |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-005 | Dual Channel Parallel Injection Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition | LEAP Shell | *DoubleStack valve *6 port injection valve *FWS in front of 6 port valve * Gradient Pump * Regeneration pump | *Integration with Analyst Software *Single Sample List *Provides staggering of injections *Multiplexes 2 separate LC systems into on MS | * Does not support 21CFR11 compliance *Requires pumps to be integrated with LEAP Shell | No |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-005 | Dual Channel Parallel Injection Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition | LEAP Shell | *DoubleStack valve *6 port injection valve *FWS in front of 6 port valve * Gradient Pump * Regeneration pump | *Integration with Analyst Software *Single Sample List *Provides staggering of injections *Multiplexes 2 separate LC systems into on MS | * Does not support 21CFR11 compliance *Requires pumps to be integrated with LEAP Shell | No |
For other cost/time saving measures consider:
- LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [1]
- Dual Channel Serial Injection (M-001) using Analyst and ICC-CE [2]
- Dual Channel Serial Injection with Front Cut (M-002) using Analyst and ICC-CE [3]
- Dual Channel Parallel Injection (M-003) using Cycle Composer Software and Analyst [4]
- “Look Ahead”, sample prep before injection (M-004) using LEAP Shell Software [5]
- Dual Channel Parallel Injection (M-005) using LEAP Shell software [6]
- LEAP Shell Software and application for custom injections and scheduling [7]
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Contact LEAP
For additional information about this technique please contact LEAP Technologies for detailed information
