Summary of LC Multi Valve Applications

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| style="border:1px solid blue;"|* Dual Stream <br>* High throughput sample cleanup "Look Ahead"
| style="border:1px solid blue;"|* Dual Stream <br>* High throughput sample cleanup "Look Ahead"
| style="border:1px solid blue;"|* Requires two matching sample lists  
| style="border:1px solid blue;"|* Requires two matching sample lists  
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| style="border:1px solid blue;"|No
 
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<br>
 
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{| cellpadding="6" style="border:1px solid darkgray;"
 
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|- align=left
 
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!width="20"|Code
 
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!width="195"|Application
 
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!width="85"|Control SW
 
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!width="140"|Key Hardware
 
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!width="205"|Key Benefits
 
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!width="235"|Restrictions
 
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!width="15"|GLP
 
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|- align=left
 
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| style="border:1px solid blue;"|'''M-007'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-006_%26_M-007_In-Line_Sample_Concentration_or_Filtration]
 
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| style="border:1px solid blue;"|'''Inline Sample Filtration'''<br><br>SPE Column regenerated during analytical extraction
 
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| style="border:1px solid blue;"|Analyst with ICC-CE
 
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| style="border:1px solid blue;"|* TrioVS<br>
 
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| style="border:1px solid blue;"|* Automated filtration of sample on cleanup column prior to separation on analytical column
 
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| style="border:1px solid blue;"|* No "Look Ahead" <br>* Can not prep samples ahead of analytical run
 
| style="border:1px solid blue;"|No
| style="border:1px solid blue;"|No
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| style="border:1px solid blue;"|Cycle Composer outside of Analyst
| style="border:1px solid blue;"|Cycle Composer outside of Analyst
| style="border:1px solid blue;"|* TrioVS<br>
| style="border:1px solid blue;"|* TrioVS<br>
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| style="border:1px solid blue;"|* Dual Stream <br>* High throughput sample cleanup "Look Ahead"
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| style="border:1px solid blue;"|* Dual Stream <br>* High throughput sample cleanup <br>* "Look Ahead"
| style="border:1px solid blue;"|* Requires two matching sample lists  
| style="border:1px solid blue;"|* Requires two matching sample lists  
| style="border:1px solid blue;"|No
| style="border:1px solid blue;"|No

Revision as of 20:13, 11 May 2009

LC Multiple Valve Applications
Application Type
  STANDARD AND SPECIAL
Application ID
 
Description
  Multiple Valve Applications for LC


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-001
[1] 		Dual Channel Serial Injection

Provides shorter cycle times by regenerating columns during next analytical run 		Analyst with ICC-CE * 6 port injection valve
* 10 port Valve
* Gradient Pump
* Regeneration pump 		* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected 		* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples 		Yes
Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-002
[2] 		Dual Channel Serial Injection with Front Cut

Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste 		Analyst with ICC-CE * Trio VS
* Gradient Pump
* Regeneration pump 		* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected
* Avoids contaminating MS inlet with early eluting compounds and solvent 		* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples 		Yes


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-003
[3] 		Dual Channel Parallel Injection

Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition 		Cycle Composer outside of Analyst * DoubleStack valve
*6 port injection valve
* FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump 		* Saving of Front and Back Cut
* Provides "Look Ahead"
* Provides staggering of injections 		* Requires matching sample lists in Cycle Composer and Analyst
* Columns may perform slightly differently on alternating samples 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-005
[4] 		Dual Channel Parallel Injection

Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition 		LEAP Shell * DoubleStack valve
* 6 port injection valve
* FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump 		* Integration with Analyst Software
* Single Sample List
* Provides staggering of injections
* Multiplexes 2 separate LC systems into on MS 		* Does not support 21CFR11 compliance
* Requires pumps to be integrated with LEAP Shell 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-006
[5] 		Inline Sample Concentration

SPE Column regenerated during analytical extraction 		Analyst with ICC-CE * TrioVS
* Automated concentration and elution of sample on SPE column prior to separation on analytical column * No "Look Ahead"
* Can not prep samples ahead of analytical run 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-007
[6] 		Inline Sample Filtration

SPE Column regenerated during analytical extraction 		Analyst with ICC-CE * TrioVS
* Automated filtration of sample on cleanup column prior to separation on analytical column * No "Look Ahead"
* Can not prep samples ahead of analytical run 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-008
[7] 		Dual Channel In-line Sample Concentration

SPE Column regenerated during analytical extraction 		Cycle Composer outside of Analyst * TrioVS
* Dual Stream
* High throughput sample cleanup "Look Ahead" 		* Requires two matching sample lists No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-009
[8] 		Dual Channel in-line Sample Filtration

SPE Column regenerated during analytical extraction 		Cycle Composer outside of Analyst * TrioVS
* Dual Stream
* High throughput sample cleanup
* "Look Ahead" 		* Requires two matching sample lists No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-010
[9] 		Dual Channel in-line Sample Concentration

SPE Column regenerated during analytical extraction 		LEAP Shell * TrioVS
* High throughput sample cleanup "Look Ahead" No


For other cost/time saving measures consider:

  • LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [10]
  • LEAP Shell Software and application for custom injections and scheduling [11]
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Contact LEAP

For additional information about this technique please contact LEAP Technologies for detailed information

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