Summary of LC Multi Valve Applications

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| style="border:1px solid blue;"|LEAP Shell
| style="border:1px solid blue;"|LEAP Shell
| style="border:1px solid blue;"|* DoubleStack valve<br>*6 port injection valve<br>* FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump
| style="border:1px solid blue;"|* DoubleStack valve<br>*6 port injection valve<br>* FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump
-
| style="border:1px solid blue;"|* Integration with Analyst Software<br>*Single Sample List<br> * Provides staggering of injections<br> * Multiplexes 2 separate LC systems into on MS
+
| style="border:1px solid blue;"|* Integration with Analyst Software<br>* Single Sample List<br> * Provides staggering of injections<br> * Multiplexes 2 separate LC systems into on MS
| style="border:1px solid blue;"|* Does not support 21CFR11 compliance<br>* Requires pumps to be integrated with LEAP Shell
| style="border:1px solid blue;"|* Does not support 21CFR11 compliance<br>* Requires pumps to be integrated with LEAP Shell
| style="border:1px solid blue;"|No
| style="border:1px solid blue;"|No

Revision as of 19:53, 11 May 2009

LC Multiple Valve Applications
Application Type
  STANDARD AND SPECIAL
Application ID
 
Description
  Multiple Valve Applications for LC


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-001
[1]
Dual Channel Serial Injection

Provides shorter cycle times by regenerating columns during next analytical run
Analyst with ICC-CE * 6 port injection valve
* 10 port Valve
* Gradient Pump
* Regeneration pump
* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected
* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples
Yes
Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-002
[2]
Dual Channel Serial Injection with Front Cut

Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste
Analyst with ICC-CE * Trio VS
* Gradient Pump
* Regeneration pump
* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected
* Avoids contaminating MS inlet with early eluting compounds and solvent
* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples
Yes


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-003
[3]
Dual Channel Parallel Injection

Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
Cycle Composer outside of Analyst * DoubleStack valve
*6 port injection valve
* FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump
* Saving of Front and Back Cut
* Provides "Look Ahead"
* Provides staggering of injections
* Requires matching sample lists in Cycle Composer and Analyst
* Columns may perform slightly differently on alternating samples
No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-005
[4]
Dual Channel Parallel Injection

Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
LEAP Shell * DoubleStack valve
*6 port injection valve
* FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump
* Integration with Analyst Software
* Single Sample List
* Provides staggering of injections
* Multiplexes 2 separate LC systems into on MS
* Does not support 21CFR11 compliance
* Requires pumps to be integrated with LEAP Shell
No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-006
[5]
Inline Sample Concentration

SPE Column regenerated during analytical extraction
Analyst with ICC-CE * TrioVS
* Automated concentration and elution of sample on SPE column prior to separation on analytical column * No "Look Ahead"
* Can not prep samples ahead of analytical run
No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-007
[6]
Inline Sample Filtration

SPE Column regenerated during analytical extraction
Analyst with ICC-CE * TrioVS
* Automated filtration of sample on cleanup column prior to separation on analytical column * No "Look Ahead"
* Can not prep samples ahead of analytical run
No


For other cost/time saving measures consider:

  • LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [7]
  • LEAP Shell Software and application for custom injections and scheduling [8]

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For additional information about this technique please contact LEAP Technologies for detailed information

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