Summary of LC Multi Valve Applications

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| style="border:1px solid blue;"|'''Dual Channel Parallel Injection'''<br><br>Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
| style="border:1px solid blue;"|'''Dual Channel Parallel Injection'''<br><br>Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
| style="border:1px solid blue;"|Cycle Composer outside of Analyst
| style="border:1px solid blue;"|Cycle Composer outside of Analyst
-
| style="border:1px solid blue;"|* DoubleStack valve<br>*6 port injection valve<br>*FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump
+
| style="border:1px solid blue;"|* DoubleStack valve<br>*6 port injection valve<br>* FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump
-
| style="border:1px solid blue;"|* Saving of Front and Back Cut<br>* Provides "Look Ahead"<br> *Provides staggering of injections
+
| style="border:1px solid blue;"|* Saving of Front and Back Cut<br>* Provides "Look Ahead"<br> * Provides staggering of injections
| style="border:1px solid blue;"|* Requires matching sample lists in Cycle Composer and Analyst<br>* Columns may perform slightly differently on alternating samples
| style="border:1px solid blue;"|* Requires matching sample lists in Cycle Composer and Analyst<br>* Columns may perform slightly differently on alternating samples
| style="border:1px solid blue;"|No
| style="border:1px solid blue;"|No
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| style="border:1px solid blue;"|'''Dual Channel Parallel Injection'''<br><br>Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
| style="border:1px solid blue;"|'''Dual Channel Parallel Injection'''<br><br>Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
| style="border:1px solid blue;"|LEAP Shell
| style="border:1px solid blue;"|LEAP Shell
-
| style="border:1px solid blue;"|*DoubleStack valve<br>*6 port injection valve<br>*FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump
+
| style="border:1px solid blue;"|* DoubleStack valve<br>*6 port injection valve<br>* FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump
-
| style="border:1px solid blue;"|*Integration with Analyst Software<br>*Single Sample List<br> *Provides staggering of injections<br> *Multiplexes 2 separate LC systems into on MS
+
| style="border:1px solid blue;"|* Integration with Analyst Software<br>*Single Sample List<br> * Provides staggering of injections<br> * Multiplexes 2 separate LC systems into on MS
-
| style="border:1px solid blue;"|* Does not support 21CFR11 compliance<br>*Requires pumps to be integrated with LEAP Shell
+
| style="border:1px solid blue;"|* Does not support 21CFR11 compliance<br>* Requires pumps to be integrated with LEAP Shell
| style="border:1px solid blue;"|No
| style="border:1px solid blue;"|No
|}
|}
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| style="border:1px solid blue;"|'''Inline Sample Concentration'''<br><br>SPE Column regenerated during analytical extraction
| style="border:1px solid blue;"|'''Inline Sample Concentration'''<br><br>SPE Column regenerated during analytical extraction
| style="border:1px solid blue;"|Analyst with ICC-CE
| style="border:1px solid blue;"|Analyst with ICC-CE
-
| style="border:1px solid blue;"|*TrioVS<br>
+
| style="border:1px solid blue;"|* TrioVS<br>
-
| style="border:1px solid blue;"|*Automated concentration and elution of sample on SPE column prior to seperation on analytical column
+
| style="border:1px solid blue;"|* Automated concentration and elution of sample on SPE column prior to separation on analytical column
-
| style="border:1px solid blue;"|* No "Look Ahead" <br>*Cant prep samples ahead of analytical run
+
| style="border:1px solid blue;"|* No "Look Ahead" <br>* Can not prep samples ahead of analytical run
| style="border:1px solid blue;"|No
| style="border:1px solid blue;"|No
|}
|}
<br>
<br>
 +
{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''M-007'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-006_%26_M-007_In-Line_Sample_Concentration_or_Filtration]
 +
| style="border:1px solid blue;"|'''Inline Sample Filtration'''<br><br>SPE Column regenerated during analytical extraction
 +
| style="border:1px solid blue;"|Analyst with ICC-CE
 +
| style="border:1px solid blue;"|* TrioVS<br>
 +
| style="border:1px solid blue;"|* Automated filtration of sample on cleanup column prior to separation on analytical column
 +
| style="border:1px solid blue;"|* No "Look Ahead" <br>* Can not prep samples ahead of analytical run
 +
| style="border:1px solid blue;"|No
 +
|}
<br>
<br>
=== For other cost/time saving measures consider:===
=== For other cost/time saving measures consider:===
* LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [http://www.leapwiki.com/mediawiki/index.php?title=Valve_Washing]
* LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [http://www.leapwiki.com/mediawiki/index.php?title=Valve_Washing]
-
* Dual Channel Serial Injection (M-001) using Analyst and ICC-CE [http://www.leapwiki.com/mediawiki/index.php?title=M-001_Dual_Channel_Serial_Injection_-_Analyst_with_ICC-CE]
 
-
* Dual Channel Serial Injection with Front Cut (M-002) using Analyst and ICC-CE [http://www.leapwiki.com/mediawiki/index.php?title=M-002_Dual_Channel_Serial_Injection_with_front_cut_-_Analyst_with_ICC-CE]
 
-
* Dual Channel Parallel Injection (M-003) using Cycle Composer Software and Analyst [http://www.leapwiki.com/mediawiki/index.php?title=M-003_Dual_Channel_Parallel_Injection_-_Cycle_Composer]
 
-
* “Look Ahead”, sample prep before injection (M-004) using LEAP Shell Software [http://www.leaptec.com/software/leap-shell-3.php]
 
-
* Dual Channel Parallel Injection (M-005) using LEAP Shell software [http://www.leapwiki.com/mediawiki/index.php?title=M-005_Dual_Channel_Parallel_Injection_-_LEAP_Shell_%22(M-Fab)%22]
 
* LEAP Shell Software and application for custom injections and scheduling [http://www.leaptec.com/software/leap-shell-3.php]
* LEAP Shell Software and application for custom injections and scheduling [http://www.leaptec.com/software/leap-shell-3.php]

Revision as of 19:51, 11 May 2009

LC Multiple Valve Applications
Application Type
  STANDARD AND SPECIAL
Application ID
 
Description
  Multiple Valve Applications for LC


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-001
[1] 		Dual Channel Serial Injection

Provides shorter cycle times by regenerating columns during next analytical run 		Analyst with ICC-CE * 6 port injection valve
* 10 port Valve
* Gradient Pump
* Regeneration pump 		* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected 		* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples 		Yes
Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-002
[2] 		Dual Channel Serial Injection with Front Cut

Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste 		Analyst with ICC-CE * Trio VS
* Gradient Pump
* Regeneration pump 		* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected
* Avoids contaminating MS inlet with early eluting compounds and solvent 		* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples 		Yes


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-003
[3] 		Dual Channel Parallel Injection

Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition 		Cycle Composer outside of Analyst * DoubleStack valve
*6 port injection valve
* FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump 		* Saving of Front and Back Cut
* Provides "Look Ahead"
* Provides staggering of injections 		* Requires matching sample lists in Cycle Composer and Analyst
* Columns may perform slightly differently on alternating samples 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-005
[4] 		Dual Channel Parallel Injection

Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition 		LEAP Shell * DoubleStack valve
*6 port injection valve
* FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump 		* Integration with Analyst Software
*Single Sample List
* Provides staggering of injections
* Multiplexes 2 separate LC systems into on MS 		* Does not support 21CFR11 compliance
* Requires pumps to be integrated with LEAP Shell 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-006
[5] 		Inline Sample Concentration

SPE Column regenerated during analytical extraction 		Analyst with ICC-CE * TrioVS
* Automated concentration and elution of sample on SPE column prior to separation on analytical column * No "Look Ahead"
* Can not prep samples ahead of analytical run 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-007
[6] 		Inline Sample Filtration

SPE Column regenerated during analytical extraction 		Analyst with ICC-CE * TrioVS
* Automated filtration of sample on cleanup column prior to separation on analytical column * No "Look Ahead"
* Can not prep samples ahead of analytical run 		No


For other cost/time saving measures consider:

  • LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [7]
  • LEAP Shell Software and application for custom injections and scheduling [8]
www.leaptec.comwww.leapwiki.com
www.leaptec.com
www.leapwiki.com

Contact LEAP

For additional information about this technique please contact LEAP Technologies for detailed information

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