LC Multi-Valve Applications

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|- align=left
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!width="20"|Code
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!width="195"|Application
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!width="85"|Control SW
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!width="140"|Key Hardware
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!width="205"|Key Benefits
 +
!width="235"|Restrictions
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!width="15"|GLP
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|- align=left
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| style="border:1px solid blue;"|'''M-001'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-001_Dual_Channel_Serial_Injection_-_Analyst_with_ICC-CE]
 +
| style="border:1px solid blue;"|'''Dual Channel Serial Injection'''<br><br>Provides shorter cycle times by regenerating columns during next analytical run
 +
| style="border:1px solid blue;"|Analyst with ICC-CE
 +
| style="border:1px solid blue;"|* 6 port injection valve<BR>* 10 port Valve <br>* Gradient Pump<br>* Regeneration pump
 +
| style="border:1px solid blue;"|* Saving of regeneration time(Back Cut)<br>* Increase throughput at little cost<br> * Control is all within Analyst<br>* Compliance is not affected
 +
| style="border:1px solid blue;"|* Can not do "Look Ahead"<br>* Injections are not staggered<br>* Peaks of interest must come of early<br>* Columns may perform slightly differently on alternating samples
 +
| style="border:1px solid blue;"|Yes
 +
|}
 +
 +
{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''M-002'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-002_Dual_Channel_Serial_Injection_with_front_cut_-_Analyst_with_ICC-CE]
 +
| style="border:1px solid blue;"|'''Dual Channel Serial Injection with Front Cut'''<br><br>Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste
 +
| style="border:1px solid blue;"|Analyst with ICC-CE
 +
| style="border:1px solid blue;"|* Trio VS<br>* Gradient Pump<br>* Regeneration pump
 +
| style="border:1px solid blue;"|* Saving of regeneration time(Back Cut)<br>* Increase throughput at little cost<br> * Control is all within Analyst<br>* Compliance is not affected <br>* Avoids contaminating MS inlet with early eluting compounds and solvent
 +
| style="border:1px solid blue;"|* Can not do "Look Ahead"<br>* Injections are not staggered<br>* Peaks of interest must come of early<br>* Columns may perform slightly differently on alternating samples
 +
| style="border:1px solid blue;"|Yes
 +
|}
 +
 +
 +
{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''M-003'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-003_Dual_Channel_Parallel_Injection_-_Cycle_Composer]
 +
| style="border:1px solid blue;"|'''Dual Channel Parallel Injection'''<br><br>Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
 +
| style="border:1px solid blue;"|Cycle Composer outside of Analyst
 +
| style="border:1px solid blue;"|* DoubleStack valve<br>* 6 port injection valve<br>* FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump
 +
| style="border:1px solid blue;"|* Saving of Front and Back Cut<br>* Provides "Look Ahead"<br> * Provides staggering of injections
 +
| style="border:1px solid blue;"|* Requires matching sample lists in Cycle Composer and Analyst<br>* Columns may perform slightly differently on alternating samples
 +
| style="border:1px solid blue;"|No
 +
|}
 +
<br>
 +
{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''M-004'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=Category:LEAP_Shell]
 +
| style="border:1px solid blue;"|'''Analyst with "Look Ahead" with LEAP Shell'''<br><br>Control of the Sample List is through LEAP Shell
 +
| style="border:1px solid blue;"|LEAP Shell
 +
| style="border:1px solid blue;"|* Standard PAL <br>* Pumps are supported within Analyst
 +
| style="border:1px solid blue;"|* "Look Ahead" <br> * Can import custom columns<br> * Freedom to create and use custom Cycles
 +
| style="border:1px solid blue;"|* Does not support 21CFR11 compliance<br>
 +
| style="border:1px solid blue;"|No
 +
|}
 +
<br>
 +
{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''M-005'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-005_Dual_Channel_Parallel_Injection_-_LEAP_Shell_%22(M-Fab)%22]
 +
| style="border:1px solid blue;"|'''Dual Channel Parallel Injection'''<br><br>Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
 +
| style="border:1px solid blue;"|LEAP Shell
 +
| style="border:1px solid blue;"|* DoubleStack valve<br>* 6 port injection valve<br>* FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump
 +
| style="border:1px solid blue;"|* Integration with Analyst Software<br>* Single Sample List<br> * Provides staggering of injections<br> * Multiplexes 2 separate LC systems into on MS
 +
| style="border:1px solid blue;"|* Does not support 21CFR11 compliance<br>* Requires pumps to be integrated with LEAP Shell
 +
| style="border:1px solid blue;"|No
 +
|}
 +
<br>
 +
{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''M-006'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-006_%26_M-007_In-Line_Sample_Concentration_or_Filtration]
 +
| style="border:1px solid blue;"|'''Inline Sample Concentration'''<br><br>SPE Column regenerated during analytical extraction
 +
| style="border:1px solid blue;"|Analyst with ICC-CE
 +
| style="border:1px solid blue;"|* TrioVS<br>
 +
| style="border:1px solid blue;"|* Automated concentration and elution of sample on SPE column prior to separation on analytical column
 +
| style="border:1px solid blue;"|* No "Look Ahead" <br>* Can not prep samples ahead of analytical run
 +
| style="border:1px solid blue;"|No
 +
|}
 +
<br>
 +
{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''M-007'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-006_%26_M-007_In-Line_Sample_Concentration_or_Filtration]
 +
| style="border:1px solid blue;"|'''Inline Sample Filtration'''<br><br>SPE Column regenerated during analytical extraction
 +
| style="border:1px solid blue;"|Analyst with ICC-CE
 +
| style="border:1px solid blue;"|* TrioVS<br>
 +
| style="border:1px solid blue;"|* Automated filtration of sample on cleanup column prior to separation on analytical column
 +
| style="border:1px solid blue;"|* No "Look Ahead" <br>* Can not prep samples ahead of analytical run
 +
| style="border:1px solid blue;"|No
 +
|}
 +
<br>
 +
{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''M-008'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-008_%26_M-009_Dual_Channel_In-Line_Sample_Concentration_or_Filtration]
 +
| style="border:1px solid blue;"|'''Dual Channel In-line Sample Concentration'''<br><br>SPE Column regenerated during analytical extraction
 +
| style="border:1px solid blue;"|Cycle Composer outside of Analyst
 +
| style="border:1px solid blue;"|* TrioVS<br>
 +
| style="border:1px solid blue;"|* Dual Stream <br>* High throughput sample cleanup "Look Ahead"
 +
| style="border:1px solid blue;"|* Requires two matching sample lists
 +
| style="border:1px solid blue;"|No
 +
|}
 +
<br>
 +
{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''M-009'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-008_%26_M-009_Dual_Channel_In-Line_Sample_Concentration_or_Filtration]
 +
| style="border:1px solid blue;"|'''Dual Channel in-line Sample Filtration'''<br><br>SPE Column regenerated during analytical extraction
 +
| style="border:1px solid blue;"|Cycle Composer outside of Analyst
 +
| style="border:1px solid blue;"|* TrioVS<br>
 +
| style="border:1px solid blue;"|* Dual Stream <br>* High throughput sample cleanup <br>* "Look Ahead"
 +
| style="border:1px solid blue;"|* Requires two matching sample lists
 +
| style="border:1px solid blue;"|No
 +
|}
 +
<br>
 +
{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''M-010'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-010_%26_M011_Dual_Channel_In-Line_Sample_Concentration_or_Filtration_-_LEAP_Shell]
 +
| style="border:1px solid blue;"|'''Dual Channel in-line Sample Concentration'''<br><br>SPE Column regenerated during analytical extraction
 +
| style="border:1px solid blue;"|LEAP Shell
 +
| style="border:1px solid blue;"|* TrioVS<br>
 +
| style="border:1px solid blue;"|* High throughput sample cleanup "Look Ahead"
 +
| style="border:1px solid blue;"|
 +
| style="border:1px solid blue;"|No
 +
|}
 +
<br>
 +
{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''M-011'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-010_%26_M011_Dual_Channel_In-Line_Sample_Concentration_or_Filtration_-_LEAP_Shell]
 +
| style="border:1px solid blue;"|'''Dual Channel in-line Sample Filtration'''<br><br>SPE Column regenerated during analytical extraction
 +
| style="border:1px solid blue;"|LEAP Shell
 +
| style="border:1px solid blue;"|* TrioVS<br>
 +
| style="border:1px solid blue;"|* High throughput sample cleanup "Look Ahead"
 +
| style="border:1px solid blue;"|
 +
| style="border:1px solid blue;"|No
 +
|}
 +
<br>
 +
{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''M-014'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=Selectable_HPLC_Streams]
 +
| style="border:1px solid blue;"|'''Selectable HPLC'''<br><br>(max 2 Streams)
 +
| style="border:1px solid blue;"|Analyst Standard Cycles
 +
| style="border:1px solid blue;"|* Two Injection Valves<br>* MS Stream Selector
 +
| style="border:1px solid blue;"|* Different Analyst Methods inject into different LC Valves <br>* Uses Standard Analyst cycles
 +
| style="border:1px solid blue;"|* Requires Analyst control of the stream selector valve <br>* Max of 2 streams can be supported
 +
| style="border:1px solid blue;"|Yes
 +
|}
 +
<br>
 +
{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''M-015'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=Selectable_HPLC_Streams]
 +
| style="border:1px solid blue;"|'''Selectable HPLC'''<br><br>(max 4 Streams)
 +
| style="border:1px solid blue;"|Analyst with ICC-CE
 +
| style="border:1px solid blue;"|* Multiple Injection Valves (serial control)<br>* PAL 10 port Valve for Stream Selector
 +
| style="border:1px solid blue;"|* Different Analyst Methods inject into different LC Valves <br>* Stream selection to MS
 +
| style="border:1px solid blue;"|* PAL controls the stream selector valve <br>* Requires Custom Cycle
 +
| style="border:1px solid blue;"|Yes
 +
|}
 +
<br>
 +
{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''M-016'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=Column_Selection]
 +
| style="border:1px solid blue;"|'''Column Selection'''<br><br> Method selects which HPLC column is in-line before injection
 +
| style="border:1px solid blue;"|Analyst with ICC-CE
 +
| style="border:1px solid blue;"|* CTC Column Selector <br>* Up to 5 columns
 +
| style="border:1px solid blue;"|* Automated switching between analytical columns within run
 +
| style="border:1px solid blue;"|* Requires Custom Cycles
 +
| style="border:1px solid blue;"|Yes
 +
|}
 +
 +
''' Contact LEAP '''
''' Contact LEAP '''
[[image:Contact_Info.png‎|40px]] [http://www.leaptec.com/contact-us.php Contact the LEAP office]
[[image:Contact_Info.png‎|40px]] [http://www.leaptec.com/contact-us.php Contact the LEAP office]
[[Category:LC Multi Valve Applications]]
[[Category:LC Multi Valve Applications]]

Revision as of 14:44, 5 October 2009

LC Multiple Valve Applications
Application Type
  STANDARD AND SPECIAL
Application ID
 
Description
  Multiple Valve Applications for LC

Overview

This summary is a sampling list of what LEAP has done and can do for you. All of these are focused on getting you Higher Throughput

Specific Categories

There are many techniques and applications that LEAP can help you with to increase sample throughput with automated injection HPLC systems. From "Front Cuts" to "Heart Cuts" to "Back Cuts" to "Multiplexing". Typical applications are pre-column SPE, pre-column cleanup, sample desalting,parallel column regeneration, etc. LEAP has the experience to solve your throughput needs. These are just a few of our offerings. We integrate multiple vendors HPLC systems and have a wide array of injection valves and selector valves to get you the best result. Many of these can be added to your existing systems to better utilize the hardware you already have.

leaptec.comleapwiki.com
leaptec.com
leapwiki.com

Videos
Movie of the HTS PAL injecting sample in valve and washing syringe.

Print
PDF of Summary LC Multi Valve_Applications page formatted for printing ‎


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-001
[1] 		Dual Channel Serial Injection

Provides shorter cycle times by regenerating columns during next analytical run 		Analyst with ICC-CE * 6 port injection valve
* 10 port Valve
* Gradient Pump
* Regeneration pump 		* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected 		* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples 		Yes
Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-002
[2] 		Dual Channel Serial Injection with Front Cut

Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste 		Analyst with ICC-CE * Trio VS
* Gradient Pump
* Regeneration pump 		* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected
* Avoids contaminating MS inlet with early eluting compounds and solvent 		* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples 		Yes


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-003
[3] 		Dual Channel Parallel Injection

Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition 		Cycle Composer outside of Analyst * DoubleStack valve
* 6 port injection valve
* FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump 		* Saving of Front and Back Cut
* Provides "Look Ahead"
* Provides staggering of injections 		* Requires matching sample lists in Cycle Composer and Analyst
* Columns may perform slightly differently on alternating samples 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-004
[4] 		Analyst with "Look Ahead" with LEAP Shell

Control of the Sample List is through LEAP Shell 		LEAP Shell * Standard PAL
* Pumps are supported within Analyst 		* "Look Ahead"
* Can import custom columns
* Freedom to create and use custom Cycles 		* Does not support 21CFR11 compliance
No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-005
[5] 		Dual Channel Parallel Injection

Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition 		LEAP Shell * DoubleStack valve
* 6 port injection valve
* FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump 		* Integration with Analyst Software
* Single Sample List
* Provides staggering of injections
* Multiplexes 2 separate LC systems into on MS 		* Does not support 21CFR11 compliance
* Requires pumps to be integrated with LEAP Shell 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-006
[6] 		Inline Sample Concentration

SPE Column regenerated during analytical extraction 		Analyst with ICC-CE * TrioVS
* Automated concentration and elution of sample on SPE column prior to separation on analytical column * No "Look Ahead"
* Can not prep samples ahead of analytical run 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-007
[7] 		Inline Sample Filtration

SPE Column regenerated during analytical extraction 		Analyst with ICC-CE * TrioVS
* Automated filtration of sample on cleanup column prior to separation on analytical column * No "Look Ahead"
* Can not prep samples ahead of analytical run 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-008
[8] 		Dual Channel In-line Sample Concentration

SPE Column regenerated during analytical extraction 		Cycle Composer outside of Analyst * TrioVS
* Dual Stream
* High throughput sample cleanup "Look Ahead" 		* Requires two matching sample lists No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-009
[9] 		Dual Channel in-line Sample Filtration

SPE Column regenerated during analytical extraction 		Cycle Composer outside of Analyst * TrioVS
* Dual Stream
* High throughput sample cleanup
* "Look Ahead" 		* Requires two matching sample lists No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-010
[10] 		Dual Channel in-line Sample Concentration

SPE Column regenerated during analytical extraction 		LEAP Shell * TrioVS
* High throughput sample cleanup "Look Ahead" No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-011
[11] 		Dual Channel in-line Sample Filtration

SPE Column regenerated during analytical extraction 		LEAP Shell * TrioVS
* High throughput sample cleanup "Look Ahead" No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-014
[12] 		Selectable HPLC

(max 2 Streams) 		Analyst Standard Cycles * Two Injection Valves
* MS Stream Selector 		* Different Analyst Methods inject into different LC Valves
* Uses Standard Analyst cycles 		* Requires Analyst control of the stream selector valve
* Max of 2 streams can be supported 		Yes


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-015
[13] 		Selectable HPLC

(max 4 Streams) 		Analyst with ICC-CE * Multiple Injection Valves (serial control)
* PAL 10 port Valve for Stream Selector 		* Different Analyst Methods inject into different LC Valves
* Stream selection to MS 		* PAL controls the stream selector valve
* Requires Custom Cycle 		Yes


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-016
[14] 		Column Selection

Method selects which HPLC column is in-line before injection 		Analyst with ICC-CE * CTC Column Selector
* Up to 5 columns 		* Automated switching between analytical columns within run * Requires Custom Cycles Yes


Contact LEAP

Contact the LEAP office

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