Small Volume Fraction Collection

From LEAP

Revision as of 01:03, 3 April 2009

	Collect PAL
	Application Type
	SPECIAL
	Application ID
	Description
	Collect PAL

Overview

The Collect PAL as shown can hold up to 24-shallow well plates and collect into either 96-well or 384-well plates. It is shown with its waste drain and high pressure valve set up. With this valve it is able to use down to 0.005” id PEEK tubing.

Compact in size, the Collect PAL covers a bench area of only 28”x28” and has a height of only 24” to the top of its Z-arm.

Key Features –

• Zero Loss Collection – most fraction collectors either are a drop-type or a solenoid driven-type.
• Zero Drips, Zero Spills
• The drop type fraction collector simply flows the effluent through tubing to a movable arm and positions the tubing over a well or tube and stays in that position for a specified time until moving to the next collection site. The main concern with this type of fraction collection is the complete lack of control over volume in the fraction site and, more importantly, the placement of each and every drop in a tube. There should be concern that sample can be lost during the “in-between” of sites during a move.
• The solenoid drive fraction collector solves the drop between sites problem by quickly switching a solenoid valve off/on during the move between wells. Drip solved, but now valuable sample during that movement is sent to a waste stream. Sample is lost to the waste.
• Neither type of fraction collection option protects what is most important – the sample -- and provides a safe environment for the researcher.

LEAP employs an inverted syringe technology, design, and control that eliminates the drops between sites and also eliminates the lost sample to waste of both drip and solenoid type fraction collectors.

The inverted Syringe and control via LEAP SHELL software

• Ability to collect through septa, capmats, plate seals. No one else can do this with ZERO LOSS. – Beats Solenoid fraction collectors
• Collect a constant, precise, user-defined volume per well or tube
• Touch-off Fraction Collection with LEAP SHELL you can send the needle to a specified height and then retract; offering a touch-off fraction collection within a well.
• 3 sec/well fraction collection available in 384-well plates.

• Deep-well, shallow-well or 2-mL vial collection set up.
• 2 Stack Configuration – Up to 12 plates or trays

• Max number of fractions per injection – Remember that you can only collect within the same collection plane. The maximum number of plates per injection available for collection = 4
• 2-mL Vials – 4x54 = 216
• 96-Well Plate – 4x96 = 384
• 384-Well Plate – 4x384 = 1536
• You can also just collect into a pre-determined number of fraction sites per plate.

Screenshots

Collect PAL System	Collect PAL	Collect PAL	Collect PAL
Collect PAL	Collect PAL	== Markets ==	DMPK
Drug Metabolism & PharmacoKinetics studies	ADMET	Adsorption ,Distribution, Metabolism, Excretion, and Toxicity – drug properties – are fundamental pharmacokinetic properties that determine the in vivo efficacy of a drug, together with its intrinsic biological activity on the target.	== Contact LEAP ==